In the West of Scotland Coronary Prevention Study (WOSCOPS), treatment of hypercholesterolemic men with pravastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, reduced their likelihood to progress to diabetes mellitus by 30%. However, the mechanism of this effect of pravastatin has not been investigated. In the current study, we examined the effect of pravastatin on the development of diabetes in obese diabetic mice, and on the insulin-induced glucose uptake and adiponectin production. Pravastatin treatment attenuated the development of diabetes in db/db and high fat/high sucrose diet-fed C57BL/6J mice. An in vivo glucose transport assay showed that pravastatin upregulated glucose uptake in adipose tissue. In...
OBJECTIVE: Adiponectin, secreted by adipose tissue, plays an important role in lipoprotein metabolis...
The US Food and Drink Administration (FDA) recently published a warning that statin usage may increa...
AbstractStatins are beneficial in the treatment of cardiovascular disease (CVD), but these lipid-low...
According to the ADA, diabetes mellitus is defined as having fasting blood glucose levels >= 7.0mmol...
We have previously demonstrated that hypercholesterolemic LDL receptor knockout (LDLr(-/-)) mice sec...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Ci...
Background-We examined the development of new diabetes mellitus in men aged 45 to 64 years during th...
Background. - In West of Scotland Coronary Prevention Study (WOSCOPS), development of type 2 diabete...
Patients with diabetes mellitus (DM), type 1 and type 2, have an increased risk of coronary heart di...
Mechanism of preventive effect of HMG-CoA reductase inhibitor on diabetic nephropathyBackgroundPrevi...
(1) Background: We aimed to demonstrate the effects of pitvastatin therapy on the serum levels of to...
New onset of diabetes is associated with the use of statins.We have recently demonstrated that prava...
Recent studies have reported that statins are associated with increased incidence of diabetes. Altho...
Objective. Type 2 diabetes mellitus is a chronic metabolic disease caused by insulin resistance or i...
Managing dyslipidaemia is central to the management of cardiovascular disease. Statins are the corne...
OBJECTIVE: Adiponectin, secreted by adipose tissue, plays an important role in lipoprotein metabolis...
The US Food and Drink Administration (FDA) recently published a warning that statin usage may increa...
AbstractStatins are beneficial in the treatment of cardiovascular disease (CVD), but these lipid-low...
According to the ADA, diabetes mellitus is defined as having fasting blood glucose levels >= 7.0mmol...
We have previously demonstrated that hypercholesterolemic LDL receptor knockout (LDLr(-/-)) mice sec...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Ci...
Background-We examined the development of new diabetes mellitus in men aged 45 to 64 years during th...
Background. - In West of Scotland Coronary Prevention Study (WOSCOPS), development of type 2 diabete...
Patients with diabetes mellitus (DM), type 1 and type 2, have an increased risk of coronary heart di...
Mechanism of preventive effect of HMG-CoA reductase inhibitor on diabetic nephropathyBackgroundPrevi...
(1) Background: We aimed to demonstrate the effects of pitvastatin therapy on the serum levels of to...
New onset of diabetes is associated with the use of statins.We have recently demonstrated that prava...
Recent studies have reported that statins are associated with increased incidence of diabetes. Altho...
Objective. Type 2 diabetes mellitus is a chronic metabolic disease caused by insulin resistance or i...
Managing dyslipidaemia is central to the management of cardiovascular disease. Statins are the corne...
OBJECTIVE: Adiponectin, secreted by adipose tissue, plays an important role in lipoprotein metabolis...
The US Food and Drink Administration (FDA) recently published a warning that statin usage may increa...
AbstractStatins are beneficial in the treatment of cardiovascular disease (CVD), but these lipid-low...