Cytokines produced by innate immune response can profoundly influence the subsequent adaptive immunity. IL-15 and -18 are two of several mediators produced by macrophages that perform such a function. Here we present recent data mainly from our own laboratory illustrating the important role of IL-15 and -18 in the induction and perpetuation of chronic inflammation during experimental and clinical rheumatoid synovitis
BACKGROUND: The T cell attracting chemokine CCL18 is produced by antigen presenting cells and a role...
BACKGROUND: The T cell attracting chemokine CCL18 is produced by antigen presenting cells and a role...
SummaryObjectiveMuch of what is known about the inflammatory response in the synovial membrane (SM) ...
Mediators produced by innate immune response cells such as macrophages can profoundly influence adap...
IL-18 is a novel cytokine with pleiotropic activities critical to the development of T-helper 1 (Th1...
Host immune and inflammatory factors contribute to progression of inflammatory synovitis – targeting...
Tumor necrosis factor-alpha occupies a central role in rheumatoid arthritis (RA) pathogenesis. We no...
IL-18 is produced by many cell types, such as Kupffer cells, keratinocytes, macrophages, dendritic c...
Interleukin 15 (IL−15) is a novel cytokine with interleukin−2−like activity. It is also a potent T−l...
The analysis of suppression of cytokines in rheumatoid synovial tissue and fluid pioneered the studi...
Bacground/Aim. Experimental in vitro and in vivo investigations in a mouse model have proved that TN...
Inflamed synovium of rheumatoid arthritis (RA) has been associated with a T helper (Th)1 cytokine pr...
Rheumatoid arthritis (RA) is a chronic disease characterised by inflammatory infiltration of the syn...
We have recently reported the presence and a potential proinflammatory role of IL-18 in the synovium...
We have investigated the mechanisms underlying IL-15-induced neutrophil migration into inflamed tiss...
BACKGROUND: The T cell attracting chemokine CCL18 is produced by antigen presenting cells and a role...
BACKGROUND: The T cell attracting chemokine CCL18 is produced by antigen presenting cells and a role...
SummaryObjectiveMuch of what is known about the inflammatory response in the synovial membrane (SM) ...
Mediators produced by innate immune response cells such as macrophages can profoundly influence adap...
IL-18 is a novel cytokine with pleiotropic activities critical to the development of T-helper 1 (Th1...
Host immune and inflammatory factors contribute to progression of inflammatory synovitis – targeting...
Tumor necrosis factor-alpha occupies a central role in rheumatoid arthritis (RA) pathogenesis. We no...
IL-18 is produced by many cell types, such as Kupffer cells, keratinocytes, macrophages, dendritic c...
Interleukin 15 (IL−15) is a novel cytokine with interleukin−2−like activity. It is also a potent T−l...
The analysis of suppression of cytokines in rheumatoid synovial tissue and fluid pioneered the studi...
Bacground/Aim. Experimental in vitro and in vivo investigations in a mouse model have proved that TN...
Inflamed synovium of rheumatoid arthritis (RA) has been associated with a T helper (Th)1 cytokine pr...
Rheumatoid arthritis (RA) is a chronic disease characterised by inflammatory infiltration of the syn...
We have recently reported the presence and a potential proinflammatory role of IL-18 in the synovium...
We have investigated the mechanisms underlying IL-15-induced neutrophil migration into inflamed tiss...
BACKGROUND: The T cell attracting chemokine CCL18 is produced by antigen presenting cells and a role...
BACKGROUND: The T cell attracting chemokine CCL18 is produced by antigen presenting cells and a role...
SummaryObjectiveMuch of what is known about the inflammatory response in the synovial membrane (SM) ...
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