Modern immunosuppressive regimens reduce the acute rejection rate by combining a cornerstone immunosuppressant like tacrolimus or cyclosporine with adjunctive agents like corticosteroids, mycophenolate mofetil (MMF) or azathioprine, often associated with untoward side effects. A 6-month randomized study was conducted in 47 European centers. Triple therapy with tacrolimus (trough levels 5–15 ng/mL), corticosteroids (dosage 10 mg/day) and MMF (1 g/day) was administered for 3 months. From day 92, patients either continued with triple therapy (control, n = 277), or stopped steroids (n = 279), or stopped MMF (n = 277). Surrogate markers for long-term benefits were changes in lipid profiles and occurrence of hematological, gastrointestinal and...
BACKGROUND. The optimal immunosuppressive regimen in kidney transplant recipients, delivering maximu...
BACKGROUND: The combination of cyclosporin, azathioprine, and prednisolone (triple immunosuppression...
Steroid-withdrawal at 3 days after renal transplantation with anti-IL-2 receptor alpha therapy: a pr...
Modern immunosuppressive regimens reduce the acute rejection rate by combining a cornerstone immunos...
Modern immunosuppressive regimens reduce the acute rejection rate by combining a cornerstone immunos...
BACKGROUND: The challenge in renal transplantation is to improve long-term patient and graft surviva...
BACKGROUND: Several multinational controlled clinical trials have shown that triple therapy immunosu...
Steroids have been included in most immunosuppressive regimens after renal transplantation, but are ...
Cyclosporine (CsA) is the current primary immunosuppressant for the prevention of renal allograft re...
- Background: Immunosuppressive regimens with the fewest possible toxic effects are desirable for tr...
BACKGROUND: The optimal immunosuppressive regimen in kidney transplant recipients, delivering maximu...
Exceptionally low acute rejection rates and excellent graft survival can be achieved with cyclospori...
BACKGROUND. The optimal immunosuppressive regimen in kidney transplant recipients, delivering maximu...
BACKGROUND: The combination of cyclosporin, azathioprine, and prednisolone (triple immunosuppression...
Steroid-withdrawal at 3 days after renal transplantation with anti-IL-2 receptor alpha therapy: a pr...
Modern immunosuppressive regimens reduce the acute rejection rate by combining a cornerstone immunos...
Modern immunosuppressive regimens reduce the acute rejection rate by combining a cornerstone immunos...
BACKGROUND: The challenge in renal transplantation is to improve long-term patient and graft surviva...
BACKGROUND: Several multinational controlled clinical trials have shown that triple therapy immunosu...
Steroids have been included in most immunosuppressive regimens after renal transplantation, but are ...
Cyclosporine (CsA) is the current primary immunosuppressant for the prevention of renal allograft re...
- Background: Immunosuppressive regimens with the fewest possible toxic effects are desirable for tr...
BACKGROUND: The optimal immunosuppressive regimen in kidney transplant recipients, delivering maximu...
Exceptionally low acute rejection rates and excellent graft survival can be achieved with cyclospori...
BACKGROUND. The optimal immunosuppressive regimen in kidney transplant recipients, delivering maximu...
BACKGROUND: The combination of cyclosporin, azathioprine, and prednisolone (triple immunosuppression...
Steroid-withdrawal at 3 days after renal transplantation with anti-IL-2 receptor alpha therapy: a pr...