Notch1 signalling is essential for the commitment of multipotent lymphocyte precursors towards the alpha beta T-cell lineage and plays an important role in regulating beta-selection in CD4(-)CD8(-) double-negative (DN) thymocytes. However, the role played by Notch in promoting the development of CD4(+)CD8(+) double-positive (DP) thymocytes is poorly characterized. Here, we demonstrate that the introduction of a constitutively active Notch1 (ICN1) construct into RAG(-/-) lymphocyte precursors resulted in the generation of DP thymocytes in in vitro T-cell culture systems. Notably, developmental rescue was dependent not only on the presence of an intact Notch1 RAM domain but also on Delta-like signals, as ICN1-induced DP development in RAG(-/-...
Thymic epithelial cells are specialized to play essential roles at multiple stages of T cell develop...
Mammalian immunity requires the presence of a broad and diverse repertoire of antigen receptors that...
T lineage development takes place outside the bone marrow (BM) in a dedicated organ, the thymus. Con...
The first checkpoint during T cell development, known as beta selection, requires the successful rea...
T-cell development in the postnatal thymus is contingent on the successful recruitment of bone marro...
Notch signaling is absolutely required for beta-selection during mouse T-cell development, both for ...
AbstractNotch signaling regulates cell fate decisions in multiple lineages. We demonstrate in this r...
Notch proteins influence cell fate decisions in many developmental systems. During lymphoid developm...
Innate T cells, which include PLZF+ T cells and innate memory CD8 SPs, represent a unique lineage of...
AbstractThe Notch receptor and its ligands are involved in many developmental processes. They are hi...
SummaryNotch1 signaling is required for T cell development and has been implicated in fate decisions...
Signaling through the Notch1 receptor is essential for T cell development in the thymus. Stromal OP9...
AbstractNotch proteins influence cell fate decisions in many developmental systems. During lymphoid ...
The generation of the cytotoxic CD8 T cell response is dependent on the functional outcomes imposed ...
In wild-type mice, T-cell receptor (TCR) gamma delta(+) cells differentiate along a CD4 CD8 double-n...
Thymic epithelial cells are specialized to play essential roles at multiple stages of T cell develop...
Mammalian immunity requires the presence of a broad and diverse repertoire of antigen receptors that...
T lineage development takes place outside the bone marrow (BM) in a dedicated organ, the thymus. Con...
The first checkpoint during T cell development, known as beta selection, requires the successful rea...
T-cell development in the postnatal thymus is contingent on the successful recruitment of bone marro...
Notch signaling is absolutely required for beta-selection during mouse T-cell development, both for ...
AbstractNotch signaling regulates cell fate decisions in multiple lineages. We demonstrate in this r...
Notch proteins influence cell fate decisions in many developmental systems. During lymphoid developm...
Innate T cells, which include PLZF+ T cells and innate memory CD8 SPs, represent a unique lineage of...
AbstractThe Notch receptor and its ligands are involved in many developmental processes. They are hi...
SummaryNotch1 signaling is required for T cell development and has been implicated in fate decisions...
Signaling through the Notch1 receptor is essential for T cell development in the thymus. Stromal OP9...
AbstractNotch proteins influence cell fate decisions in many developmental systems. During lymphoid ...
The generation of the cytotoxic CD8 T cell response is dependent on the functional outcomes imposed ...
In wild-type mice, T-cell receptor (TCR) gamma delta(+) cells differentiate along a CD4 CD8 double-n...
Thymic epithelial cells are specialized to play essential roles at multiple stages of T cell develop...
Mammalian immunity requires the presence of a broad and diverse repertoire of antigen receptors that...
T lineage development takes place outside the bone marrow (BM) in a dedicated organ, the thymus. Con...