SINTESIS MAGNETIT-HIDROTALSIT SEBAGAI HOST PELEPASAN ION MEFENAMAT

Synthesis of Mg/Al hydrotalcite and magnetite-hydrotalcite intercalated mefenamate ion has been attempted. Synthesis was performed by coprecipitation method with Mg/Al mol ratio of 2, Mg/Fe of 10 and hydrothermal treatment at 100 °C for 15 hours. Mefenamate ion intercalation into the interlayer Mg/Al NO3� hydrotalcite was done by ion exchange reaction. Kinetics of ion exchange and release of mefenamate ion in matrices material has also been studied. XRD data after ion exchange showed that changes in the interlayer basal spacing (d003) magnetite-hydrotalcite before and after intercalation is 8.77 � to 22.35 �. FTIR Spectra showed symmetry and asymmetry carboxylate groups at 1381 and 1612 cm�1. Anion exchange reaction of NO3� by mefenamate ion followed second order kinetics. Release test performed from 30 to 360 min showed the optimum conditions of release of mefenamate ion from magnetitehydrotalcite matrix is obtained fully after 180 minutes