OPTIMASI FORMULA MATRIKS TRANSDERMAL PENTAGAMAVUNON-0 DENGAN KOMBINASI POLIMER PVP DAN METILSELULOSA MENGGUNAKAN SIMPLEX LATTICE DESIGN

Transdermal delivery system is possible to transport PGV-0. This study was aimed 1) to formulate PGV-0 transdermal matrix with optimal physicochemical characteristics and release rate, 2) to establish the in vitro transport profile of transdermal PGV-0 across the skin. The combination of PVP and methylcellulose in transdermal matrix of PGV-0 was determined by Design Expert 7.1.5. The physicocemical characteristics consist of weight, thickness, % moisture content, % moisture uptake, folding endurance, and drug content were evaluated. PGV-0 release rate was tested using Millipore membrane in a vertical diffusion cells for 6 hours. Optimization of the matrix formula was performed based on the significant responses. Transdermal transport study was carried out on optimal formula using vertical diffusion cell and full-thickness rat skin for 24 hours. The entire formulas could produce uniform and flexible transdermal matrices. The combination of PVP and methylcellulose had a significant influence on the weight, thickness, drug content, and dissolution efficiency of PGV-0 transdermal matrix. The combination of 2.436 % PVP and 1.564 % methylcellulose as an optimal formula produces light yellow, flat, and flexible PGV-0 transdermal matrix. The optimal matrix had weight of 0.304 g, thickness of 0.378 mm, drug content of 101.37 %, and dissolution efficiency of 21.33%. The release results of optimal matrix was analyzed using compartement model method. The data results indicates that the release profile of PGV-0 from transdermal matrix follow 4 compartements model with 2 compartements lag. The optimal formula of transdermal matrix could not transport PGV-0 across the skin