PENGARUH EKSTRAK METHANOL TUMBUHAN Hoodia macrantha SEBAGAI PENEKAN NAFSU MAKAN TERHADAP MEMORI SPASIAL MENCIT JANTAN

Background : Hoodia macrantha is plants that are found in Kalahari South Africa. This plant commonly used by local residents as appetite suppressor. Recent research has found a substance called P57 and it is believed that responsible in suppressing appetite. Nowadays, there are many companies producing substances to be marketed without further research. Weight problems have been a universal problem and consumption of slimming drugs become a routine for people without knowing effects. This research will examine the influence of Hoodia macrantha methanol extract to spatial memory arrangement of male mice. Objective : The purpose of this research is to know the influence of Hoodia macrantha methanol extract to memory special arrangement of male mice with oral route. Methods : Hoodia macrantha plant was 12 months old and extracted using methanol. The making of the suspension using a dose of 0, 5, 15, and 50 mg/kgBB/hari/1mL. Mice were divided into 4 groups according to the dose. Extract administered once a day for 7 days. 24 hours after the administration spatial memory was measured using Morris water maze with 3 trial for 3 days and sensorymotor observations on the third day. The data obtained from the observations were analyzed using oneway ANOVA. If p> 0.05 then the result is significant, p <0.05, it is not significant. Results : The results of the comparison between groups. In trial 1 obtained p = 0.891, p = 0.958 trial 2, trial 3 p = 0.465, and trial 4 (sensorimotor) p = 0.781. There were no significant results (p> 0.05). Conclusion : Methanol extract of Hoodia macrantha with doses of 5, 15, and 50 mg/kgBB/hari/1mL, does not affect spatial memory of male mice