PENGARUH PENAMBAHAN ASAM HIALURONAT PADA DEMINERALIZED FREEZE-DRIED BOVINE BONE XENOGRAFT TERHADAP KEBERHASILAN PERAWATAN KERUSAKAN INTRABONI

Periodontal regeneration treatment can be performed using bone graft material. Hyaluronic acid is a natural non- sulfate glycosaminoglycan found in the extracellular matrix and contribute to proliferation and migration of cells. The aim of this study to find out effect hyaluronic acid-suppemented Demineralized Freeze-Dried Bovine Bone Xenograft (DFDBBX) to correction intrabony defects. This study was done toward 4 patients chronic periodontitis with intrabony defect and probing depth > 4 mm were divided into 2 groups treatment. First group was treated by flap operation with DFDBBX added(+) hyaluronic acid and second group was treated by flap operation with DFDBBX added(+) physiological fluids. Data were obtained at baseline before treatment and 3 months after treatment include Probing Depth (PD), Clinical Attachment Loss (CAL), and Intrabony Pocket Depth (IBPD). Data PD, CAL, and IBPD analyzed using the Mann-Whitney test with a significance level of 95 % . The results showed PD reduction in group DFDBBX+hyaluronic acid was 3,593±1,448 mm compared group DFDBBX+physiological fluid was 3,136±0,888 mm (p>0,05). CAL reduction in group DFDBBX+hyaluronic acid was 3,259±1,631 mm compared group DFDBBX+physiological fluid was 1,773±1,192 mm (p<0,05). IBPD reduction in group DFDBBX+hyaluronic acid was 1,333 ± 0,912 mm compared group DFDBBX+physiological fluid was 0,708±0,450 mm (p