HUBUNGAN ANTARA ASAM HYALURONAT DENGAN INDEKS FIB-4 PADA PENDERITA HEPATITIS KRONIK DENGAN DAN TANPA SIROSIS HATI

Cirrhosis of the liver is a journey final path ology of various diseases liver . World Health Organization ( WHO ) provides limits histology liver cirrh osis as the diffuse abnormality, marked fibrosis and normal liver changes shape to form abnormal nodules. Currently has developed asses sment of liver fibrosis by non invasive examination and routine laboratory specialized laboratory that is based on examina tion scores and examination FIB � 4 index plasma le vels of hyaluronic acid . Many previous studies which concluded that a second examination proved to be able to assess the severity of fibrosis . So far there have not b een studies linking between FIB - 4 index with an examination of plasma levels of hyaluronic acid . This study was conduc ted to determine the association between plasma levels of hyaluronic acid with fibrosis assessment by FIB - 4 index in patients with chronic hepatitis with and without liver cirrhosis. The method used i n this study is crosssectional. The study was conducted in the clinic and ward gastroenterohepatologi Medicine Hospital Dr . Sardjito. Inclusion criteria were patients with a diagnosis of chronic hepatitis and liver cirrh osis based on clinical criteria , laboratory and li ver ultrasound, patients aged > 18 years, following the research a nd willing to approach approval. Exclusion criteria were the presence of osteoarthritis, rheumatoid arthritis, diabetes mellitus, malignancy, psoriasis, multiple sclerosis and sepsis . The me an plasma hyaluronic acid levels of patients with chronic hepatitis without liver cirrhosis were 176 ± 10, 2 7 µg / L and FIB - 4 index of 1,8± 1, 61 whereas in patients chronic hepatitis with liver cirrhosis obtained mean plasma hyalu ronic acid levels were 25 6 ± 18, 84 µ g / L and FIB - 4 index was 5, 7 ± 4, 0 4. T he association between hyaluronic acid with FIB - 4 index in chronic hepatitis with and without liver cirrhos is was positive correlation ( r = 0 , 5