EVALUASI IN VIVO PHOROUS BOVINE BIPHASIC CALCIUM PHOSPHATE SEBAGAI BAHAN SUBSTITUSI GAP TULANG PADA RATTUS NOVERGICUS

Introduction: The development of economically affordable bonegraft is needed for orthopaedic practice. Synthetic phorous biphasic calcium phosphate could be produced from bovine bone. Objective: To evaluate the application of phorous bovine biphasic calcium phosphate compared to commercial phorous hydroxyapatite graft as bonegraft on animal model. Methods: This study comprise of graft manufacturing process using bovine bone as calcium resource for phorous biphasic calcium phosphate production. Graft implantation procedure of researched material and commercial hydroxtapatite was conducted on twenty critical size defect of Rattus novergicus femur. X-Ray evaluation was performed at the day of implantation and at teh 28 days after implantation. All rats were killed at 4th week after surgery. Result: After thermal heating process up to 1300°C, we have managed to form biphasic calcium phosphate. The following animal implantation also showed no significant difference on radiologic (ISOLS) score compare to the commercial graft based on Mann Whitney U test with p = 0,536 (p > 0, 05). Conclusion: Phorous bovine biphasic calcium phosphate graft has equal outcome on bone healing with regards to the commercial porous hydroxyapatite graft