ANALISIS DOSIS DI ORGAN KRITIS PADA TERAPI GLIOBLASTOMA DENGAN BORON NEUTRON CAPTURE THERAPY MENGGUNAKAN METODE SIMULASI MCNP5

Glioblastoma is the highest grade of brain tumour and poor prognosis so the progression of this tumour is very fast. One type of glioblastoma therapy is Boron Neutron Capture Therapy. Boron Neutron Capture Therapy is a therapy that utilizes the absorption interaction of Boron-10 with thermal neutron. This study was intended to determine the radiation dose and efficacy of BNCT treatment by modelings and simulations. This study was a simulation-based experiment using MCNP5. Firstly, the geometry and composition of the brain and object under study and radiation source were defined. MCNP5 was used to simulate neutron interactions that occured in the brain. The obtained output data from MCNP5 simulations were neutron flux, neutron scattering dose, and photon dose from collimator. These neutron flux data were the used in BNCT dose calculations. Based on calculations, the best concentration of Boron-10 in tumour tissue was 25-35 µg/g tumour. The irradiation directions used were superior direction and anteroposterior direction. In this case, lateral irradiation direction could not be used because the distance between the neutron source and the tumour was too far. By using appropriate irradiation direction and concentration of boron, the radiation dose in skin was found to be less than 3 Gy. The optimal distance of source and tumour was 2.4 cm. Irradiation time required was 3.5517 h (10 µg boron/g tumour