Daya guna aminofilin dibanding kafein disamping terapi untuk mencegah apnea bayi kurang bulan

Apnea of prematurity (AOP) usually occurs in neonates with a gestational age < 34 weeks. The world health organization has recommended the administration of caffeine or aminophylline to prevent AOP, but the efficacy of aminophylline is still controversial, whereas caffeine citrate is not available in Indonesia. This study aims to determine the efficacy of aminophylline compared to caffeine to prevent AOP despite of its therapy. This was a single-blind clinical trial and was conducted to neonates (gestational age 28-43 weeks) who were able to breathe spontaneously within the first 24 hours of life and admitted to Sanglah Hospital during December 2012-April 2013. We allocated the subjects into two therapy groups with six permutation block. We followed the subjects from the first day of birth until ten day old. We gave therapy to the subjects for seven days. The comparable for efficacy between two groups were assessed by Chisquare test with 95% confidence interval and a statistical significance value of P < 0.05. We used logistic regression test to analysis the confounding factors. Sixty nine subjects participated in this study, 48 subjects received aminophylline therapy and the other 48 subjects received caffeine therapy. Twenty eight subjects experienced apne