UJI SENSITIVITAS RIFAMPISIN TERHADAP METHICILLIN-RESISTANT Staphylococcus aureus SECARA IN VITRO

Background : Methicillin-Resistant Staphylococcus aureus is one of main pathogen causing infection in human beings. Methicillin-Resistant Staphylococcus aureus infections is often severe and hard to treat because it�s capability to resists any beta lactams antibiotics and its fast ability to develop resistant against various antibiotics. Even, some of strains are found to be resistant against Vancomycin that has been a drug of choice to treat this bacterial infection. Rifampicin is known as its use to treat Tuberculosis and its bactericide effect againts some microorganism like Staphylococci Objectives : To know Rifampicin sensitivity against Methicillin Resistant Staphylococcus aureus with in vitro approach. Method : This study used observational design. The materials were Rifampicin antibiotic and Methicillin-Resistant Staphylococcus aureus isolate collections of Laboratorium of Microbiology Faculty of Medicine Universitas Gadjah Mada. Minimal Inhibitory Concentration (MIC) of Rifampicin against Methicillin-Resistant Staphylococcus aureus were examined using Macrobroth Dilution and match it with CLSI standard. Results : Minimal Inhibitory Concentration (MIC) of 13 Methicillin-Resistant Staphylococcus aureus isolates tested against Rifampicin were 76,92% sensitive, 7,69% intermediate, dan 15,38% resistant. Conclusion : Rifampicin has antibacterial effect and still sensitive againts Methicillin-Resistant Staphylococcus aureu