PENGARUH KONSENTRASI EKSTRAK DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis)TERHADAP JUMLAH PEMBULUH DARAH PADA PENYEMBUHAN LUKA GINGIVA TIKUS PUTIH (Rattus norvegicus)

Wound healing is the complex and dynamic process that results in the restoration of anatomical continuity and function. Angiogenesis is formation of new blood vessels which is one component of wound healing, can restore the blood supply to wounded tissue. Binahong was proven as a wound healing accelerator for it�s phytochemical properties, such as flavonoid, saponin, alkaloid, flavonoid, and ascorbic acid. The aim of this study was to investigate the effect of extract of binahong�s leaves on gingival wound healing process in white rats in term of blood vessels� count. Forty five rats were wounded by punch biopsy with diameter of 2.5 mm at gingival mucosa above the front teeth of upper and lower jaws with a depth untill periosteum tissues, then separated into five groups : first group was given 0% extract (negative control), second group was given 10% extract of binahong leaves, third group was given 20% extract of binahong leaves, fourth group was given 40% extract of binahong leaves, and fifth group was given povidone iodine 10% (positive control). Wound tissue taken at 3rd, 5th, and 7th days and processed into histological sample preparations with Mallory�s staining. The result of two way ANOVA showed that there was significant effect for treatment and the day to blood vessels� count (p<0,05). Extract of binahong leaves concentration of 10% had the highest mean on 3rd and 5th day, while on the 7th day the highest mean was binahong 40% extract. LSD test between treatment group with highest mean from each days and negative control showed no significant difference (p>0,05)