PENGARUH PEMBERIAN TEPUNG GEMBILI (Dioscorea esculenta) TERHADAP TOTAL KOLESTEROL DAN HDL DARAH TIKUS WISTAR YANG DIINDUKSI NIKOTINAMIDE- STREPTOZOTOSIN

Background: Diabetes mellitus type 2 is a disease caused by impaired insulin production or insulin resistance resulting in hyperglycemia. Insulin resistance causes the increasing activity of triglyceride�s hidrolysis that generates excessive free fatty acids which in turn cause abnormal lipid metabolism (dyslipidemia). Dyslipidemia diabetic is characterized by high level of total cholesterol and low HDL cholesterol which are a risk factor for atherosclerosis. Resistant starch and dietary fiber have the ability to reduce total cholesterol and raise HDL cholesterol. Gembili is one of the local tuber that contains a lot of resistant starch. Objective: To determine the effect of flour gembili on levels of total cholesterol and HDL blood of Wistar rats which are induced by nicotinamide and streptozotocin. Methods: Quasi-experimental research design study with pre and post test with control group design was performed on 30 Wistar rats aged 2 months weighing ± 200 g that were divided into 5 groups. Group K.S is the normal rats, group K.