PENGARUH PEMBERIAN EKSTRAK RIMPANG KUNYIT (Curcuma domestica Val.) TERHADAP GAMBARAN HISTOPATOLOGIS PARU-PARU YANG DIINDUKSI ASAP ROKOK PADA TIKUS PUTIH WISTAR

An increasing number of smokers, have caused the increasing numbers of incidencies of the lung diseases from year to year. To prevent the number of smokers, it is not only needed social approaches, but also preventive and/or therapeutic approaches, mainly through the herbs which might be able to have phytopreventive effect on pathologic lesions of the lungs due to cigarette smokes. Cigarette smoke have negative impact to both the smokers, and also the surrounding environment. This present study is aimed to observe and determine the effects of turmeric (Curcuma domestica Val.) extract administration towards the cytotoxicity effect of cigarette smoke in the lungs of Wistar rats. Twenty male Wistar rats were used and divided randomly into four groups, of five each. Group I is as a control (K I), Group II was given 9 cigarettes/day without turmeric extract administration (K II), Group III given turmeric extract 1 ml 0.25%/day (K III) and Group IV was given 9 cigarettes/day and turmeric extract 0.25%/day (K IV) for 60 days. At the end of the present study, all rats were necropsied and organs, particularly the lungs were collected, processed histopatologically and stained routenely with hematoxilyn eosin. The results indicated that the lungs had macrophages infiltration in the septal alveoli and hyperplasia of bronchial associated lymphoid tissue (K II). Whereas, the lungs in the rats in Groups K I, K III and K IV were still within the normal limits. It is concluded, that turmeric extract may have a potential anti pulmonary cytotoxity effect due to cigarette smoke