GAMBARAN MIKROSKOPIK KOLAGEN PADA JARINGAN LUKA IRIS KULIT ANJING (Canis familiaris) HARI KE 14 YANG DITERAPI SALEP EKSTRAK DAUN BINAHONG (Anredera cordifolia)

The research was conducted to study the microscopic figures of the density of collagen in the dog skin incision wound that treated by hexane fraction ointment of binahong leaf extract 5% and 10% concentration. Four (4) local female dogs, aged 4-6 months were used in this research. The dogs adapted for 1 week and given anthelmintic of ivermectin. Incisions made after adaptation was completed, as much as 3 incisions (group A, B and C) on each dog on the right side of the abdomen with a 6 cm along the vertical direction. The group A incision wounds as the control group given no treatment, the group B incision wounds given a treatment of ointment binahong leaf extract 5% hexane fraction and the group C incision wounds given ointment treatment binahong leaf extract 10% hexane fraction. At day 14th, tissue samples of wound healing which has been linked, taken measuring 2 x 2 cm, put into formalin 10% then sent to the Laboratory of Histology Faculty of Veterinary Medicine for making a preparations of histology with Trichrome Mallory staining. The results showed that microscopic examination of collagen density in group B and group C is more dense than in group A. Statistical analysis using the T-test showed that there is no significant differences between the control and 5% treatment binahong leaf extract ointment (P>0.1), but significantly different (P