PERBANDINGAN ONSET DAN KEJADIAN HIPOTENSI ANTARA PROPOFOL LCT DENGAN PROPOFOL MCT/LCT

Background. Propofol is an intravenous anesthetic drug that most commonly used today. Propofol used for induction, maintenance of anesthesia and sedation both inside and outside the operating room. Induction of anesthesia with propofol is associated with several side effects such as hypotension and pain of injection. Propofol formula was initially used a concentration of 10 mg/ml in long-chain triglyceride (LCT) fatty emulsion. Propofol MCT/LCT has been introduce since 1995 to reduce moderate to severe pain due to injection of propofol. Since concentration of free propofol in propofol MCT/LCT lower than propofol LCT, it will affect the potency and onset time. More free drug fraction in plasma means the drug more potent and rapid onset. Purpose. To determine the onset and incidence of hypotension between propofol LCT and propofol MCT/LCT. Methods. The design of the study was a randomized double blind controlled trial ( RCT). Total study subjects were 66 patients, divided into two groups, each group consist of 33 patients. Group A was the group who received propofol LCT 2 mg/kg and group B was the group who received propofol MCT/LCT 2 mg/kg. Inclusion criteria were men and women aged 18-60 years, ASA I and II, elective surgery procedures other than neurosurgery, cardiac surgery and cesarean section, and BMI> 20 and <30 kg/m2. The exclusion criteria were patients with cardiovascular disorders such as heart disease, hypertension, patients with endocrine disorders such as diabetes mellitus, hyperthyroidism, hypothyroidism, impaired renal function, patients taking antiarrhythmic drugs, vasopresor, vasodilator and a history of allergy to propofol. Result. There were no significant differences in the onset of propofol between group A and group B either by eyelash reflex disappeared (p = 0.339) or hand grip opened (p = 0.783). There were also no significant difference in both systolic and diastolic blood pressure (p> 0.05). Summary. Propofol LCT with more free drugs than propofol MCT/LCT, did not have a faster onset and larger hypotension effect than propofol MCT/LCT