Obesitas sentral berhubungan dengan toleransi glukosa terganggu pada remaja perempuan = Central obesity is associated with impaired glucose tolerance in female adolescents

Background: Obesity in adolescents has become health problem in Indonesia. Central obesity is associated with insulin resistance. Theoretically, insulin resistance will cause impaired glucose tolerance (IGT) and could develop into type 2 diabetes. Objective: The aim of this study were to evaluate the difference in IGT prevalence between central and non central obesity and to identify the risk factors associated with IGT. Method: A cross sectional study was conducted at 3 private secondary schools in Yogyakarta and recruited 62 obese female students aged 12-18 years.The subjects were classified into central obesity (BMI/U> +2SD and waist circumference > p90) and non central obesity based on anthropometric data. Fasting glucose and 2 hours after loading were measured in all subjects. Differences in the proportion of IGT between the two groups was calculated by Chi-square test and risk factors associated with IGT were calculated by multivariate logistic regression with 95% confidence interval. Results: Of 62 subjects, 14 of them have IGT and the prevalence of IGT was significantly higher in the central obesity group compared to non central obesity group (11/31 vs 3/31, p=0.03). Central obesity was found to be the only risk factor of IGT (OR=4.