Efek Renoprotektif Nifedipin Pada Gagal Ginjal Akut Iskemik Akibat Penjepitan Arteri Renalis Bilateral : Percobaan pada Kucing Teranestesi

ABSTRACT Calcium antagonist has been known had capability in augmentation of renal hemodynamic that enhanced glomerular filtration rate (GFR). This capability indicates that calcium antagonist has potency as renoprotector agent. The aim of this study was to study about the renoprotective effect of nifedipine in ischemic acute renal failure (ARF) by 1 hour bilateral renal artery clamping. Ten healthily cats, female and male, various strains, body weight about 2.37+1.31 kg involved in this study, using pre test - post test design. Subject was anaesthetised with ether for induction, and maintained with alfa-chloralose IV. 50 100/ KgBW in 5% borax solution. There were five treatment conditions i.e., basal condition (B) began after hemodynamic status was stable after preparation, clamping condition (C) began after bilateral renal artery was clamped, post-damping condition (PC) began after release renal artery clamping, blanko condition (BL) began after giving the subject 5 cc aquadest via gastric tube, and nifedipine condition (N) began after giving the subject nifedipine 0,54 mg in 5cc aquadest via gastric tube to estimate glomerular filtration rate (GFR) in every condition, plasma creatinin concentration, urine creatinin concentration, and urine production/minute were measured to calculate creatinin clearance. Mean artery pressure (MAP) measured every 5 minutes, to observe the hemodynamic condition. In the end of observation, the kidneys removed for histopatological examination to compare with normal kidney. The result showed that GFR were decreased very significantly (