Efek Pemberian Panax ginseng Terhadap Kadar Malondialdehyde (MDA) dan Superoxide Dismutase (SOD) Darah Pada Latihan Fisik Aerobik Intensitas Sedang = The Effect of Panax ginseng Supplementation on Blood ...

Abstrak Strenuous and moderate intensity physical exercises may enhance oxygen uptake, leading to increase metabolism, which in turn may increase the production of free radical molecules. The rise of free radical molecules concentration which exceed the protective capacity of antioxidant defense systems may induces an oxidative stress. Ginseng is regarded as a natural ergo-genic aid and has been known as supplement to improve physical performance. Ginseng has been assumed to protect against exercise-induced oxidative stress. The aim of this study was to explore the effects of P. ginseng C. A. Meyer G115 supplementation on the level of blood MDA and SOD during moderate aerobic exercise. A pretest-posttest control group design was used in this experiment involved 18 healthy young adult. Subjects were randomly assigned to ginseng (n = 6) vitamin C (n = 6) or placebo (n = 6) treatment group. Each participant received a standardized extract of P. ginseng C.A. Meyer G115 200 mg per day (ginseng group) or vitamin C 250 mg (vitamin C group) or placebo (placebo group) for 11 weeks. Subjects of the three groups participated in a three-day-per-week moderate intensity aerobic exercise program for eleven weeks. Before and after this eleven weeks program, fasting blood samples were obtained, and MDA and SOD as an index of oxidative stress were studied. Seventeen subject completed the study. One subject dropped-out because of sickness. There were no significant difference in MDA and SOD (p>0,05) between ginseng, vitamin C, and placebo treatment group. The results of this study indicated that extract P.ginseng C.A. Meyer G115 supplementation 200 mg per day for eleven weeks did not decrease blood MDA level and increase blood SOD lev el during moderate aerobic exercise. Keywords: Panax ginseng, MDA, SOD, exercis