Does protective measurement imply the reality of the wave function?

Recently the first protective measurement has been realized in experiment [Nature Phys. 13, 1191 (2017)], which can measure the expectation value of an observable from a single quantum system. This raises an important and pressing issue of whether protective measurement implies the reality of the wave function. If the answer is yes, this will improve the influential PBR theorem [Nature Phys. 8, 475 (2012)] by removing auxiliary assumptions, and help settle the issue about the nature of the wave function. In this paper, we demonstrate that this is indeed the case. It is shown that a psi-epistemic model and quantum mechanics have different predictions about the variance of the result of a Zeno-type protective measurement with finite N