This paper addresses a specific way of using representational models to construct other models, dubbed ‘generative constructive use’. This use is distinguished from other ways of using models to construct new models. In particular, the case study shows how the model, in coordination with its target, opens up or extends a domain of investigation by suggesting and generating new targets and thereby prompting and enabling new forms of empirical investigation. That suggests that, in this case, it is the model in coordination to its target, rather than the model alone, that should be regarded as an epistemic tool. This use is philosophically important because it is what makes some models scientifically significant. Even though these models are s...