Biological insights from 108 schizophrenia-associated genetic loci.
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Publication date
January 2014
DOI Publisher
Nature Publishing Group Journal
issn:1476-4687Abstract
To access publisher's full text version of this article click on the hyperlink at the bottom of the pageSchizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirel...