Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
- Perry, John R B
- Voight, Benjamin F
- Yengo, Loïc
- Amin, Najaf
- Dupuis, Josée
- Ganser, Martha
- Grallert, Harald
- Navarro, Pau
- Li, Man
- Qi, Lu
- Steinthorsdottir, Valgerdur
- Scott, Robert A
- Almgren, Peter
- Arking, Dan E
- Aulchenko, Yurii
- Balkau, Beverley
- Benediktsson, Rafn
- Bergman, Richard N
- Boerwinkle, Eric
- Bonnycastle, Lori
- Burtt, Noël P
- Campbell, Harry
- Charpentier, Guillaume
- Collins, Francis S
- Gieger, Christian
- Green, Todd
- Hadjadj, Samy
- Hattersley, Andrew T
- Herder, Christian
- Hofman, Albert
- Johnson, Andrew D
- Kottgen, Anna
- Kraft, Peter
- Labrune, Yann
- Langenberg, Claudia
- Manning, Alisa K
- Mohlke, Karen L
- Morris, Andrew P
- Oostra, Ben
- Pankow, James
- Petersen, Ann-Kristin
- Pramstaller, Peter P
- Prokopenko, Inga
- Rathmann, Wolfgang
- Rayner, William
- Roden, Michael
- Rudan, Igor
- Rybin, Denis
- Scott, Laura J
- Sigurdsson, Gunnar
- Sladek, Rob
- Thorleifsson, Gudmar
- Thorsteinsdottir, Unnur
- Tuomilehto, Jaakko
- Uitterlinden, Andre G
- Vivequin, Sidonie
- Weedon, Michael N
- Wright, Alan F
- Hu, Frank B
- Illig, Thomas
- Kao, Linda
- Meigs, James B
- Wilson, James F
- Stefansson, Kari
- van Duijn, Cornelia
- Altschuler, David
- Morris, Andrew D
- Boehnke, Michael
- McCarthy, Mark I
- Froguel, Philippe
- Palmer, Colin N A
- Wareham, Nicholas J
- Groop, Leif
- Frayling, Timothy M
- Cauchi, Stéphane
DOIAbstract
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.Common diseases such as type 2 diabetes are phenotypically heterogeneous. Obesity is a major risk factor for type 2 diabetes, but patients vary appreciably in body mass index. We hypothesized that the genetic predisposition to the disease may be different in lean (BMI<25 Kg/m²) compared to obese cases (BMI≥30 Kg/m²). We performed two case-control genome-wide studies using two accepted cut-offs for defining individuals as overweight or obese. We used 2,112 lean type 2 diabetes cases (BMI<25 kg/m²) or 4,123 obese cases (BMI≥30 kg/m²), and 54,412 un-stratified controls. Replication was performed in 2,881 lean cases or 8,702 obese ca...
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