Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium.
- Kerkhof, H J M
- Meulenbelt, I
- Akune, T
- Arden, N K
- Aromaa, A
- Bierma-Zeinstra, S M A
- Carr, A
- Cooper, C
- Dai, J
- Doherty, M
- Doherty, S A
- Felson, D
- Gonzalez, A
- Gordon, A
- Harilainen, A
- Hart, D J
- Hauksson, V B
- Heliovaara, M
- Hofman, A
- Ikegawa, S
- Ingvarsson, T
- Jiang, Q
- Jonsson, H
- Jonsdottir, I
- Kawaguchi, H
- Kloppenburg, M
- Kujala, U M
- Lane, N E
- Leino-Arjas, P
- Lohmander, L S
- Luyten, F P
- Malizos, K N
- Nakajima, M
- Nevitt, M C
- Pols, H A P
- Rivadeneira, F
- Shi, D
- Slagboom, E
- Spector, T D
- Stefansson, K
- Sudo, A
- Tamm, A
- Tamm, A E
- Tsezou, A
- Uchida, A
- Uitterlinden, A G
- Wilkinson, J M
- Yoshimura, N
- Valdes, A M
- van Meurs, J B J
DOIAbstract
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field.OBJECTIVE: To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes. METHODS: Descriptions of OA phenotypes of the 28 studies involved in the TREAT-OA consortium were collected. We investigated whether different OA definitions result in different association results by creating various hip OA definitions in one large population based cohort (the Rotterdam Study I (RSI)) and testing those for association with gender, age and body mass index using one-way ANOVA. For ROA, we standardized the hip-, knee- an...
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