Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.
- Gudmundsson, Julius
- Sulem, Patrick
- Rafnar, Thorunn
- Bergthorsson, Jon T
- Manolescu, Andrei
- Gudbjartsson, Daniel
- Agnarsson, Bjarni A
- Sigurdsson, Asgeir
- Benediktsdottir, Kristrun R
- Blondal, Thorarinn
- Jakobsdottir, Margret
- Stacey, Simon N
- Kostic, Jelena
- Kristinsson, Kari T
- Birgisdottir, Birgitta
- Ghosh, Shyamali
- Magnusdottir, Droplaug N
- Thorlacius, Steinunn
- Thorleifsson, Gudmar
- Zheng, S Lilly
- Sun, Jielin
- Chang, Bao-Li
- Elmore, J Bradford
- Breyer, Joan P
- McReynolds, Kate M
- Bradley, Kevin M
- Yaspan, Brian L
- Wiklund, Fredrik
- Stattin, Par
- Lindström, Sara
- Adami, Hans-Olov
- McDonnell, Shannon K
- Schaid, Daniel J
- Cunningham, Julie M
- Wang, Liang
- Cerhan, James R
- St Sauver, Jennifer L
- Isaacs, Sara D
- Wiley, Kathleen E
- Partin, Alan W
- Walsh, Patrick C
- Polo, Sonia
- Ruiz-Echarri, Manuel
- Navarrete, Sebastian
- Fuertes, Fernando
- Saez, Berta
- Godino, Javier
- Weijerman, Philip C
- Swinkels, Dorine W
- Aben, Katja K
- Witjes, J Alfred
- Suarez, Brian K
- Helfand, Brian T
- Frigge, Michael L
- Kristjansson, Kristleifur
- Ober, Carole
- Jonsson, Eirikur
- Einarsson, Gudmundur V
- Xu, Jianfeng
- Gronberg, Henrik
- Smith, Jeffrey R
- Thibodeau, Stephen N
- Isaacs, William B
- Catalona, William J
- Mayordomo, Jose I
- Kiemeney, Lambertus A
- Barkardottir, Rosa B
- Gulcher, Jeffrey R
- Thorsteinsdottir, Unnur
- Kong, Augustine
- Stefansson, Kari
DOIAbstract
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/OpenWe conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease
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