Cytogenetic patterns in ETV6/RUNX1-positive pediatric B-cell precursor acute lymphoblastic leukemia: A Nordic series of 245 cases and review of the literature.
- Forestier, Erik
- Andersen, Mette K
- Autio, Kirsi
- Blennow, Elisabeth
- Borgström, Georg
- Golovleva, Irina
- Heim, Sverre
- Heinonen, Kristina
- Hovland, Randi
- Johannsson, Johann H
- Kerndrup, Gitte
- Nordgren, Ann
- Rosenquist, Richard
- Swolin, Birgitta
- Johansson, Bertil
DOIAbstract
To access publisher full text version of this article. Please click on the hyperlink in Additional Link fieldBetween 1992 and 2004, 1,140 children (1 to<15 years) were diagnosed with B-cell precursor acute lymphoblastic leukemia (ALL) in the Nordic countries. Of these, 288 (25%) were positive for t(12;21)(p13;q22) [ETV6/RUNX1]. G-banding analyses were successful in 245 (85%); 43 (15%) were karyotypic failures. The modal chromosome numbers, incidence, types, and numbers of additional abnormalities, genomic imbalances, and chromosomal breakpoints in the 245 karyotypically informative cases, as well as in 152 previously reported cytogenetically characterized t(12;21)-positive ALLs in the same age group, were ascertained. The most common modal ...
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