Retinitis pigmentosa (RP) is a degenerative disease leading to photoreceptor cell loss. Mouse models of RP, such as the rd10 mouse (B6.CXBl-Pde6brd10/J), have enhanced our understanding of the disease, allowing for development of potential therapeutics. In 2011, our group first demonstrated that the synthetic progesterone analogue ‘Norgestrel’ is neuroprotective in two mouse models of retinal degeneration, including the rd10 mouse. We have since elucidated several mechanisms by which Norgestrel protects stressed photoreceptors, such as upregulating growth factors. This study consequently aimed to further characterize Norgestrel’s neuroprotective effects. Specifically, we sought to investigate the role that microglia might play; for microgli...
Enhancing the endogenous capacity of myelin repair is a major therapeutic challenge in demyelinating...
<div><p>Demyelination occurs widely in neurodegenerative diseases. Progesterone has neuroprotective ...
<p>Retinitis pigmentosa (RP) is a group of inherited retinopathies characterized by photoreceptors d...
Retinitis pigmentosa (RP) is a degenerative disease leading to photoreceptor cell loss. Mouse models...
Retinitis pigmentosa (RP) is a degenerative disease leading to photoreceptor cell loss. Mouse models...
Retinitis pigmentosa (RP) encompasses a group of retinal diseases resulting in photoreceptor loss an...
Purpose: Retinitis pigmentosa (RP) refers to a group of inherited blinding retinal diseases, whereby...
Purpose: Retinitis pigmentosa (RP) refers to a group of inherited blinding retinal diseases, whereby...
Retinitis pigmentosa (RP) involves a group of hereditary diseases that cause progressive and severe ...
Retinitis pigmentosa (RP) is a group of hereditary retinal diseases, characterised by photoreceptor ...
Retinitis pigmentosa (RP) is one of the most common retinal degenerative conditions affecting people...
<p><b>(A)</b> 661W cells were serum-starved and treated with 20μM Norgestrel or the equivalent DMSO ...
AbstractRetinitis pigmentosa (RP) is one of the most common retinal degenerative conditions affectin...
Purpose: The purpose of this study was to test the hypothesis that anti-oxidant and / or anti-inflam...
Retinitis pigmentosa (RP) is a degenerative retinal disease leading to photoreceptor cell loss. In 2...
Enhancing the endogenous capacity of myelin repair is a major therapeutic challenge in demyelinating...
<div><p>Demyelination occurs widely in neurodegenerative diseases. Progesterone has neuroprotective ...
<p>Retinitis pigmentosa (RP) is a group of inherited retinopathies characterized by photoreceptors d...
Retinitis pigmentosa (RP) is a degenerative disease leading to photoreceptor cell loss. Mouse models...
Retinitis pigmentosa (RP) is a degenerative disease leading to photoreceptor cell loss. Mouse models...
Retinitis pigmentosa (RP) encompasses a group of retinal diseases resulting in photoreceptor loss an...
Purpose: Retinitis pigmentosa (RP) refers to a group of inherited blinding retinal diseases, whereby...
Purpose: Retinitis pigmentosa (RP) refers to a group of inherited blinding retinal diseases, whereby...
Retinitis pigmentosa (RP) involves a group of hereditary diseases that cause progressive and severe ...
Retinitis pigmentosa (RP) is a group of hereditary retinal diseases, characterised by photoreceptor ...
Retinitis pigmentosa (RP) is one of the most common retinal degenerative conditions affecting people...
<p><b>(A)</b> 661W cells were serum-starved and treated with 20μM Norgestrel or the equivalent DMSO ...
AbstractRetinitis pigmentosa (RP) is one of the most common retinal degenerative conditions affectin...
Purpose: The purpose of this study was to test the hypothesis that anti-oxidant and / or anti-inflam...
Retinitis pigmentosa (RP) is a degenerative retinal disease leading to photoreceptor cell loss. In 2...
Enhancing the endogenous capacity of myelin repair is a major therapeutic challenge in demyelinating...
<div><p>Demyelination occurs widely in neurodegenerative diseases. Progesterone has neuroprotective ...
<p>Retinitis pigmentosa (RP) is a group of inherited retinopathies characterized by photoreceptors d...