The goal of my thesis is to optimize the route for replacement of bus schedules in Prague. This task deals with the role of the Traveling Salesman Problem, which belongs to the class NP-hard problems. The solution is numerically very difficult and is gained by using the system LINGO and by using optimization solver Gurobi. The task is modified so that the total time traveled by vehicles does not exceed the specified value. In my thesis I first characterize the problem of replacement of bus schedules. Following chapter is devoted to the role of Traveling Salesman Problem, its history, definitions, problems to solve, possibilities of solution and modification of the tasks on Traveling Salesman Problem with more vehicles. The last chapter deal...