Salt overload in fructose-fed insulin-resistant rats decreases paraoxonase-1 activity.
- Dornas, Waleska Claudia Amaral
- Lima, Wanderson Geraldo de
- Santos, Rinaldo Cardoso dos
- Souza, Melina Oliveira de
- Silva, Ma?sa
- Diniz, Mirla Fiuza
- Silva, Marcelo Eust?quio
DOIAbstract
Paraoxonase 1 (PON1) is a HDL-associated esterase/lactonase and its activity is inversely related to the risk of cardiovascular diseases. The aim of the present study was to evaluate the effect of a high-salt diet on serum PON1 activity in fructose-fed insulin-resistant rats. Adult male Fischer rats were initially divided into two groups. Control (CON), which received a normal salt diet and drinking water throughout the study; high fructose (HF), which received a normal salt diet and 20% fructose supplemented drinking water. After 10 weeks, half of the animals from HF group were randomly switched to a high-salt diet and 20% fructose supplemented drinking water (HFS) for more 10 weeks. Serum PON1 activity was determined by synthetic substrat...
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