Chapter 6 : Bone marrow masenchymal cell contribution in maintenance of periodontal ligament homeostasis.

In general, remodeling phenomenon of the periodontal ligament (PDL) is occurring in all times. Thus, in the chapter, the word “maintenance” was used, and the chapter title is “Maintenance of Periodontal Ligament Homeostasis.” Our experimental data on the remodeling of the PDL with cell acceleration at the furcation area in this experimental model are recovered using the cells in situ and the bone marrow-derived cells (BMCs).BMC migration into the PDL tissues using green Ěuorescent protein (GFP)bone marrow-transplanted model mouse was examined. BMCs have abilities of cell migration and diěerentiation into tissues/organs in the body. The immunohistochemistry revealed that GFP-positive cells were detected in the PDL.GFP-positive cells were also positive to CD31, CD68, and Runx2 suggesting that ębroblasts diěerentiated into osteoclasts and tissue macrophages. In this way, Notch signaling involvement considered in our tentative examinations revealed that the experimentally induced periodontal polyp was examined; the cytological dynamics of the cells in granulation tissue are mainly from migration of undiěerentiated mesenchymal cells of the bone marrow and diěerentiate into the tissue-specięed cells. Furthermore, the data suggest that cell diěerentiation is due to Notch signaling.Edited by Thomas Heinbockel and Vonnie D.C. Shields : Published in London : IntechOpen, 2019