辅酶Q10在他汀类药物相关肌病中的应用与进展

Statins have been widely used, however, the reports of muscle toxicity caused by statins are increasing. Coenzyme Q10 is a quinone substance which is in the cell membrane, and it is important material of intercellular signaling, mitochondrial respiratory chain and muscle activity energy. The myopathic symptoms can be significantly improved by taking coenzyme Q10.他汀类药物是胆固醇合成酶系中的限速酶(羟甲基戊二酸单酰辅酶A还原酶)抑制剂，是目前临床广泛应用的调血脂药物，但是其引起的肌肉毒性的报道也日益增多，限制了临床长期足量应用。辅酶Q10是存在于细胞膜中一种苯醌物质，是细胞间信号传导、线粒体呼吸链以及肌肉活动能量需要的重要物质。通过补充辅酶Q10，肌病症状可以得到明显改善。