The research progress of pressure ulcers and action mechanism of negative pressure wound therapy

压力性溃疡（PU）作为截瘫、昏迷及各种原因导致的长时间卧床患者的常见并发症，从最初的理论研究到现在的临床实践，其治疗方法产生了重大变化。负压创面疗法(NPWT）作为近20年来兴起的技术，其封闭、负压等特点，可以针对性作用于PU病程中的各种机制，在治疗PU方面取得了良好的临床效果。本文就PU的病因及发病机制研究进展及NPWT在PU治疗中的作用做一综述。Pressure ulcer (PU) is a common complication in patients with long time lying in bed due to paraplegia, coma and various reasons. It has produced significant changes in clinical practice from the initial theoretical study to the present clinical practice. As the new rising technology in the nearly 20 years, negative pressure wound therapy (NPWT) can be targeted at the various mechanisms of PU due to its closeness, negative pressure and other characteristics. It has achieved good curative effect in the treatment of PU. This article reviews the research progress on the etiology and pathogenesis of PU, and the role of NPWT in the treatment of PU