Genetic analysis in a mouse as an laboratory animal.

The mouse is the most useful and widely used experimental animal in biomedical research, teaching, and testing. The remarkable genetic similarity of mice to humans, combined with great convenience, perhaps accounts for mice so often being the experimental model of choice in research. About a research of mice, there is accumulation of enormous data such as gene marker, genome sequence and EST. Gene targeting has enabled researchers to generate mousu strains with defined mutations in their genome alloowing the analysis of gene function in vivo. This review presents the essential tools and methodologies used for genetic analysis that have been developed over the past decade