Due to the increasing need of new treatment options against bacterial lung infections, novel antimicrobial peptides (AMPs) are under development. Local bioavailability and less systemic exposure lead to the inhalation route of administration. Combining AMPs with nanocarriers (NCs) into nanosystems (NSs) might be a technique for improved results. An air-liquid interface (ALI) in vitro inhalation model was set up including a human alveolar lung cell line (A549) and an optimized exposure system (P.R.I.T.® ExpoCube®) to predict acute local lung toxicity. The approach including aerosol controls (cupper-II-sulfate and lactose) delivered lowest observable adverse effect levels (LOAELs). Different combinations of AMPs (AA139, M33) and NCs (polymeri...
The alveolar epithelium of the lung is by far the most permeable epithelial barrier of the human bod...
Nanoparticles (NP)-based inhalation systems for drug delivery can be administered in liquid form, by...
International audienceNanoparticles (NPs) are potentially toxic for humans, especially after inhalat...
Due to the increasing need of new treatment options against bacterial lung infections, novel antimic...
While searching for effective antibiotics against resistant bacteria, nanocompounds are developed to...
Concerns for the toxic effects of airborne nanoparticles have been raised along with the increasing ...
The introduction of engineered nanostructured materials into a rapidly increasing number of industri...
Animal experiments are still the gold standard to assess inhalation toxicology of nanomaterials (NM...
A new prototype airliquid interface (ALI) exposure system, a flatbed aerosol exposure chamber termed...
A new prototype air–liquid interface (ALI) exposure system, a flatbed aerosol exposure chamber terme...
In light of the increasingly abundant use of engineered nanoparticles(NPs) and the ongoing exposure ...
International audienceBackground : Recently, much progress has been made to develop more physiologic...
Diverse industries have already incorporated within their production processes engineered nanopartic...
Inhalation is a non-invasive approach for both local and systemic drug delivery. This study aimed to...
Background: Inhalation of aerosolized drugs is a promising route for noninvasive targeted drug deliv...
The alveolar epithelium of the lung is by far the most permeable epithelial barrier of the human bod...
Nanoparticles (NP)-based inhalation systems for drug delivery can be administered in liquid form, by...
International audienceNanoparticles (NPs) are potentially toxic for humans, especially after inhalat...
Due to the increasing need of new treatment options against bacterial lung infections, novel antimic...
While searching for effective antibiotics against resistant bacteria, nanocompounds are developed to...
Concerns for the toxic effects of airborne nanoparticles have been raised along with the increasing ...
The introduction of engineered nanostructured materials into a rapidly increasing number of industri...
Animal experiments are still the gold standard to assess inhalation toxicology of nanomaterials (NM...
A new prototype airliquid interface (ALI) exposure system, a flatbed aerosol exposure chamber termed...
A new prototype air–liquid interface (ALI) exposure system, a flatbed aerosol exposure chamber terme...
In light of the increasingly abundant use of engineered nanoparticles(NPs) and the ongoing exposure ...
International audienceBackground : Recently, much progress has been made to develop more physiologic...
Diverse industries have already incorporated within their production processes engineered nanopartic...
Inhalation is a non-invasive approach for both local and systemic drug delivery. This study aimed to...
Background: Inhalation of aerosolized drugs is a promising route for noninvasive targeted drug deliv...
The alveolar epithelium of the lung is by far the most permeable epithelial barrier of the human bod...
Nanoparticles (NP)-based inhalation systems for drug delivery can be administered in liquid form, by...
International audienceNanoparticles (NPs) are potentially toxic for humans, especially after inhalat...