Applications of protein-based capacitive biosensors for the detection of heavy-metal ions
- Mortari, A
- Brown, NL
- Geczy, C
- Coster, HGL
- Valenzuela, SM
- Martin, D
- Csöregi, E
Publication date
December 2006
DOI Publisher
Institute of Electrical and Electronics Engineers (IEEE)Abstract
Three different methods of using protein-based capacitive biosensors for the detection of heavy-metal ions are presented. The metal-binding proteins SmtA, S100A12, MerP and four modified MerPs were immobilised as the biorecognition element on self-assembled monolayer-modified gold electrodes. Capacitance was measured using potential square step or electrical impedance spectroscopy. The protein-metal interaction generated changes in capacitance mainly due to a protein conformational change. © 2006 IEEE
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