Cystic fibrosis (CF) lung disease is an inherited condition with an incidence rate of approximately 1 in 2500 new born babies. CF is characterized as chronic infection of the lung which leads to inflammation of the airway. Sputum from CF patients contains elevated levels of neutrophils and subsequently elevated levels of neutrophil serine proteases. In a healthy individual these proteases aid in the phagocytic process by degrading microbial peptides and are kept in homeostatic balance by cognate antiproteases. Due to the heavy neutrophil burden associated with CF the high concentration of neutrophil derived proteases overwhelms cognate antiproteases. The general effects of this protease/antiprotease imbalance are impaired mucus clearance, i...
$\textbf{BACKGROUND}$ Pathogenic bacteria which chronically colonise the cystic fibrosis (CF) lung ...
International audienceNeutrophil serine proteases in cystic fibrosis (CF) lung secretions partially ...
Proteases identified in the lung were initially thought to be involved in extracellular matrix destr...
Cystic fibrosis (CF) is a lethal disorder characterized by abnormal epithelial ion transport; this d...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
Chronic inflammatory lung diseases such as cystic fibrosis and emphysema are characterized by higher...
Background: In cystic fibrosis (CF) airways excessive levels of serine trypsin-like proteases (TLP) ...
ABSTRACT: Significant airway remodelling is a major component of the increased morbidity and mortali...
Neutrophil serine proteases (NSPs) especially elastase are major agents of lung destruction in cysti...
ABSTRACT: Progressive lung disease determines the morbidity and mortality of cystic fibrosis (CF) pa...
Cystic fibrosis (CF) is a high-prevalence disease characterized by significant lung remodeling, resp...
Airway mucins are the major molecular constituents of mucus. Mucus forms the first barrier to invadi...
Airway mucins are the major molecular constituents of mucus. Mucus forms the first barrier to invadi...
he contribution of the neutrophil-derived serine pro-tease neutrophil elastase (NE) to lung disease ...
In cystic fibrosis (CF) infectious and allergic airway inflammation cause pulmonary exacerbations th...
$\textbf{BACKGROUND}$ Pathogenic bacteria which chronically colonise the cystic fibrosis (CF) lung ...
International audienceNeutrophil serine proteases in cystic fibrosis (CF) lung secretions partially ...
Proteases identified in the lung were initially thought to be involved in extracellular matrix destr...
Cystic fibrosis (CF) is a lethal disorder characterized by abnormal epithelial ion transport; this d...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
Chronic inflammatory lung diseases such as cystic fibrosis and emphysema are characterized by higher...
Background: In cystic fibrosis (CF) airways excessive levels of serine trypsin-like proteases (TLP) ...
ABSTRACT: Significant airway remodelling is a major component of the increased morbidity and mortali...
Neutrophil serine proteases (NSPs) especially elastase are major agents of lung destruction in cysti...
ABSTRACT: Progressive lung disease determines the morbidity and mortality of cystic fibrosis (CF) pa...
Cystic fibrosis (CF) is a high-prevalence disease characterized by significant lung remodeling, resp...
Airway mucins are the major molecular constituents of mucus. Mucus forms the first barrier to invadi...
Airway mucins are the major molecular constituents of mucus. Mucus forms the first barrier to invadi...
he contribution of the neutrophil-derived serine pro-tease neutrophil elastase (NE) to lung disease ...
In cystic fibrosis (CF) infectious and allergic airway inflammation cause pulmonary exacerbations th...
$\textbf{BACKGROUND}$ Pathogenic bacteria which chronically colonise the cystic fibrosis (CF) lung ...
International audienceNeutrophil serine proteases in cystic fibrosis (CF) lung secretions partially ...
Proteases identified in the lung were initially thought to be involved in extracellular matrix destr...