The risk of ovarian cancer increases with an increase in the lifetime number of ovulatory cycles: an analysis from the ovarian cancer cohort consortium (OC3)
- Trabert, B
- Tworoger, SS
- O'Brien, KM
- Townsend, MK
- Fortner, RT
- Iversen, ES
- Hartge, P
- White, E
- Amiano, P
- Arslan, AA
- Bernstein, L
- Brinton, LA
- Buring, JE
- Dossus, L
- Fraser, GE
- Gaudet, MM
- Giles, GG
- Gram, IT
- Harris, HR
- Bolton, JH
- Idahl, A
- Jones, ME
- Kaaks, R
- Kirsh, VA
- Knutsen, SF
- Kvaskoff, M
- Lacey, J
- Lee, I-M
- Milne, RL
- Onland-Moret, NC
- Overvad, K
- Patel, A
- Peters, U
- Poynter, JN
- Riboli, E
- Robien, K
- Rohan, TE
- Sandler, DP
- Schairer, C
- Schouten, LJ
- Setiawan, VW
- Swerdlow, AJ
- Travis, RC
- Trichopoulou, A
- Van den Brandt, PA
- Visvanathan, K
- Wilkens, LR
- Wolk, A
- Zeleniuch-Jacquotte, A
- Wentzensen, N
DOIAbstract
Repeated exposure to the acute proinflammatory environment that follows ovulation at the ovarian surface and distal fallopian tube over a woman's reproductive years may increase ovarian cancer risk. To address this, analyses included individual-level data from 558,709 naturally menopausal women across 20 prospective cohorts, among whom 3,246 developed invasive epithelial ovarian cancer (2,045 serous, 319 endometrioid, 184 mucinous, 121 clear cell, 577 other/unknown). Cox models were used to estimate multivariable-adjusted HRs between lifetime ovulatory cycles (LOC) and its components and ovarian cancer risk overall and by histotype. Women in the 90th percentile of LOC (>514 cycles) were almost twice as likely to be diagnosed with ovarian ca...
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