Rechnergestützte Therapie unter Berücksichtigung patientenspezifischer Biomechanik

Computer-assisted methods have emerged in medical diagnosis and therapy planning. Thereby the planning often relies on a 3D model of the anatomical structures reconstructed from medical image data (CT, MRT, US). Within this dissertation the diagnostic possibilities are enhanced by combining the model generation of with a simulation of the patient specific biomechanics. Not only image data also biomechanical parameters are considered in the simulation. The pathologic function can be analyzed within the simulation, this analysis is combined with a description of the planned intervention and it results in a prediction of the therapy outcome and the change of functionality caused by the planned intervention. Using this approach different biomechanical phenomena have been examined in different medical application fields: Static analyses have been performed to specify an optimal prosthesis for the implantation of an artificial knee joint, a simulation of the patient specific jaw movement helps to detect occlusions and to verify the design of onlays and crowns in dental diagnostics. Stress-strain simulation is applied in spine surgery and flow simulation has been used in ENT medicine to analyze the patient-specific air flow in the nose. For the presented approaches not only the diagnostic method is presented also an evaluation strategy is outlined that can be applied to proof the significance of the simulation. The presented work results in an approach registering biomedical parameters in real-time and considering these parameters in a Virtual Reality based method for whiplash therapy