Nuclear organization of chromatin is an important level of genome regulation with positional changes of genes occurring during reprogramming. Inherent variability of biological specimens, wide variety of sample preparation and imaging conditions, though pose significant challenges to data analysis and comparison. Here, we describe the development of a computational image analysis toolbox overcoming biological variability hurdles by a novel single cell randomizing normalization. We performed a comparative analysis of the relationship between spatial positioning of pluripotency genes with their genomic activity and determined the degree of similarity between fibroblasts, induced pluripotent stem cells and embryonic stem cells. Our analysis re...
Forced expression of reprogramming factors can convert somatic cells into induced pluripotent stem c...
International audienceRelating genotypes with phenotypes is important to understand diseases like ca...
Forced expression of reprogramming factors can convert somatic cells into induced pluripotent stem c...
Nuclear organization of chromatin is an important level of genome regulation with positional changes...
Nuclear organization of chromatin is an important level of genome regulation with positional changes...
Nuclear organization of chromatin is an important level of genome regulation with positional changes...
BACKGROUND Heterochromatin has been reported to be a major silencing compartment during developme...
Pluripotent genomes are folded in a topological hierarchy that reorganizes during differentiation. T...
Nuclear architecture in tissues can arise from cell-type specific organization of nuclear bodies, ch...
It is becoming increasingly clear that the shape of the genome importantly influences transcription ...
DNA is packaged into chromosomes, which occupy a specific region in the three-dimensional (3D) nucle...
The genome has long been believed to be more or less randomly arranged in the nucleus. However, rece...
SummaryForced expression of reprogramming factors can convert somatic cells into induced pluripotent...
Identifying the relationships between chromosome structures, nuclear bodies, chromatin states and ge...
Background: Heterochromatin has been reported to be a major silencing compartment during development...
Forced expression of reprogramming factors can convert somatic cells into induced pluripotent stem c...
International audienceRelating genotypes with phenotypes is important to understand diseases like ca...
Forced expression of reprogramming factors can convert somatic cells into induced pluripotent stem c...
Nuclear organization of chromatin is an important level of genome regulation with positional changes...
Nuclear organization of chromatin is an important level of genome regulation with positional changes...
Nuclear organization of chromatin is an important level of genome regulation with positional changes...
BACKGROUND Heterochromatin has been reported to be a major silencing compartment during developme...
Pluripotent genomes are folded in a topological hierarchy that reorganizes during differentiation. T...
Nuclear architecture in tissues can arise from cell-type specific organization of nuclear bodies, ch...
It is becoming increasingly clear that the shape of the genome importantly influences transcription ...
DNA is packaged into chromosomes, which occupy a specific region in the three-dimensional (3D) nucle...
The genome has long been believed to be more or less randomly arranged in the nucleus. However, rece...
SummaryForced expression of reprogramming factors can convert somatic cells into induced pluripotent...
Identifying the relationships between chromosome structures, nuclear bodies, chromatin states and ge...
Background: Heterochromatin has been reported to be a major silencing compartment during development...
Forced expression of reprogramming factors can convert somatic cells into induced pluripotent stem c...
International audienceRelating genotypes with phenotypes is important to understand diseases like ca...
Forced expression of reprogramming factors can convert somatic cells into induced pluripotent stem c...