Add to ORKGSchizophrenia is a devastating psychiatric illness that affects 1-2% of the world population and continues as a challenge to neuroscience. In this work, we describe an account about the historical evolution of the dopaminergic hypothesis of schizophrenia discussing, from the medicinal chemistry point of view all different classes of antipsychotic drugs, emphasizing the rational design, structure activity relationships (SAR) and physico-chemical properties related with its molecular mechanism of action
When “antipsychotic ” drugs were introduced into psychiatry in the 1950s, they were thought to work ...
OBJECTIVE: The clinical hallmark of schizophrenia is psychosis. The objective of this overview is to...
The dopamine hypothesis of schizophrenia has been one of the most enduring ideas in psychiatry. Init...
Schizophrenia is a devastating psychiatric illness that affects 1-2% of the world population and con...
Schizophrenia is a devastating psychiatric illness that affects 1-2% of the world population and con...
Schizophrenia is a devastating psychiatric illness that affects 1-2% of the world population and con...
The dopamine hypothesis of schizophrenia, which was formulated in the 1960s after the discovery of t...
In psychiatry, pharmacological drugs play an important experimental role in attempts to identify the...
For the past decade, the dopamine hypothesis of schizophrenia has been the predominant biochemi-cal ...
Advances in knowledge of brain neurochemistry have lent impetus to the biological study of schizo-ph...
Dopamine is an inhibitory neurotransmitter involved in the pathology of schizophrenia. The revised d...
When drug-induced psychoses were first identified in the mid-20th century, schizophrenia was conside...
Every so often in the history of medicine, events occur which in retrospect seem to mark a defining ...
The neurodegenerative and neurodevelopmental hypotheses represent the basic etiological framework fo...
Schizophrenia is perhaps the most devastating neuropsychiatric illness. Worldwide, its prevalence ra...
When “antipsychotic ” drugs were introduced into psychiatry in the 1950s, they were thought to work ...
OBJECTIVE: The clinical hallmark of schizophrenia is psychosis. The objective of this overview is to...
The dopamine hypothesis of schizophrenia has been one of the most enduring ideas in psychiatry. Init...
Schizophrenia is a devastating psychiatric illness that affects 1-2% of the world population and con...
Schizophrenia is a devastating psychiatric illness that affects 1-2% of the world population and con...
Schizophrenia is a devastating psychiatric illness that affects 1-2% of the world population and con...
The dopamine hypothesis of schizophrenia, which was formulated in the 1960s after the discovery of t...
In psychiatry, pharmacological drugs play an important experimental role in attempts to identify the...
For the past decade, the dopamine hypothesis of schizophrenia has been the predominant biochemi-cal ...
Advances in knowledge of brain neurochemistry have lent impetus to the biological study of schizo-ph...
Dopamine is an inhibitory neurotransmitter involved in the pathology of schizophrenia. The revised d...
When drug-induced psychoses were first identified in the mid-20th century, schizophrenia was conside...
Every so often in the history of medicine, events occur which in retrospect seem to mark a defining ...
The neurodegenerative and neurodevelopmental hypotheses represent the basic etiological framework fo...
Schizophrenia is perhaps the most devastating neuropsychiatric illness. Worldwide, its prevalence ra...
When “antipsychotic ” drugs were introduced into psychiatry in the 1950s, they were thought to work ...
OBJECTIVE: The clinical hallmark of schizophrenia is psychosis. The objective of this overview is to...
The dopamine hypothesis of schizophrenia has been one of the most enduring ideas in psychiatry. Init...