Acute and chronic electroconvulsive shock in rats : effects on peripheral markers of neuronal injury and glial activity

  • Busnello, Joao Vicente
  • Leke, Renata
  • Oses, Jean Pierre
  • Feier, Gustavo
  • Brüch, Ricardo Santalucia
  • Quevedo, João Luciano de
  • Kapczinski, Flávio Pereira
  • Souza, Diogo Onofre Gomes de
  • Portela, Luis Valmor Cruz
Publication date
January 2006
Journal
Life Sciences

Abstract

Electroconvulsive therapy is considered one of the most effective treatments of major depression, but controversy still exists on whether it may be brain damaging. The aim of this work was to evaluate the cerebrospinal fluid (CSF) levels of neuron specific enolase (NSE), protein S100B and lactate of rats submitted to acute and chronic models of ECS. Rats were submitted to either one shock (acute) or a series of eight shocks, applied one at every 48 h (chronic). CSF samples were collected at 0, 3, 6, 12, 24, 48 and 72 h after the shock in the acute model and at these same time intervals after the last shock in the chronic model. Both models did not produce significant alterations in the levels of NSE. S100B levels were significantly increase...

Extracted data

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