Abstract Background MAPK/ERK kinases transmit signals from many growth factors/kinase receptors during normal cell growth/differentiation, and their dysregulation is a hallmark of diverse types of cancers. A plethora of drugs were developed to block this kinase pathway for clinical application. With the exception of a recently identified agent, EQW, most of these inhibitors target upstream factors but not ERK1/2; no activator of ERK1/2 is currently available. Method A library of compounds isolated from medicinal plants of China was screened for anti-cancer activities. Three limonoid compounds, termed A1541–43, originally isolated fro...
AbstractTangeretin is a methoxyflavone from citrus fruits, which inhibits growth of human mammary ca...
The extracellular signal-regulated kinase (ERK) pathway is a major determinant in the control of div...
Abstract Background The extracellular signal-regulated kinase-1 and 2 (ERK1/2) proteins play an impo...
Abstract Background MAPK/ERK kinases transmit signals...
Abstract Background Cholesterol plays vital roles in human physiology; abnormal levels have deleteri...
Melanoma is the deadliest form of skin cancer with a dramatically increasing incidence rate over the...
The mitogen-activated protein kinases (MAPK) pathway, often known as the RAS-RAF-MEK-ERK signal casc...
EHEB leukemic cells, which are derived from a patient suffering B-cell chronic lymphocytic leukemia ...
The RAS-mitogen-activated protein kinase (MAPK) signaling pathway has a central role in regulating t...
The scaffold diversity of natural products has given rise to the development of many drugs. Around o...
International audienceSimalikalactone E (SkE) is a quassinoid extracted from a widely used Amazonian...
The incidence of melanoma, the most fatal dermatological cancer, has dramatically increased over the...
Ethnopharmacological relevance: Ervatamia coronaria, a popular garden plant in India and some other ...
Clinically used BCR-ABL1 inhibitors for the treatment of chronic myeloid leukemia do not eliminate l...
© 2007 American Association for Cancer ResearchProtein kinases represent promising anticancer drug t...
AbstractTangeretin is a methoxyflavone from citrus fruits, which inhibits growth of human mammary ca...
The extracellular signal-regulated kinase (ERK) pathway is a major determinant in the control of div...
Abstract Background The extracellular signal-regulated kinase-1 and 2 (ERK1/2) proteins play an impo...
Abstract Background MAPK/ERK kinases transmit signals...
Abstract Background Cholesterol plays vital roles in human physiology; abnormal levels have deleteri...
Melanoma is the deadliest form of skin cancer with a dramatically increasing incidence rate over the...
The mitogen-activated protein kinases (MAPK) pathway, often known as the RAS-RAF-MEK-ERK signal casc...
EHEB leukemic cells, which are derived from a patient suffering B-cell chronic lymphocytic leukemia ...
The RAS-mitogen-activated protein kinase (MAPK) signaling pathway has a central role in regulating t...
The scaffold diversity of natural products has given rise to the development of many drugs. Around o...
International audienceSimalikalactone E (SkE) is a quassinoid extracted from a widely used Amazonian...
The incidence of melanoma, the most fatal dermatological cancer, has dramatically increased over the...
Ethnopharmacological relevance: Ervatamia coronaria, a popular garden plant in India and some other ...
Clinically used BCR-ABL1 inhibitors for the treatment of chronic myeloid leukemia do not eliminate l...
© 2007 American Association for Cancer ResearchProtein kinases represent promising anticancer drug t...
AbstractTangeretin is a methoxyflavone from citrus fruits, which inhibits growth of human mammary ca...
The extracellular signal-regulated kinase (ERK) pathway is a major determinant in the control of div...
Abstract Background The extracellular signal-regulated kinase-1 and 2 (ERK1/2) proteins play an impo...