Evaluation of the radioprotective ability of cystamine for 150 keV-500 MeV proton irradiation: a Monte Carlo track chemistry simulation study.

Cystamine, an organic diamino-disulfide, is among the best of the known radiation-protective compounds although the underlying molecular mechanisms by which it operates remain poorly understood. This study aims to use the aqueous ferrous sulfate (Fricke) dosimeter to evaluate, from a radiation chemistry viewpoint, the protective properties of this compound when present during irradiation by fast incident protons in the energy range of 150 keV-500 MeV or, equivalently, for “linear energy transfer” (LET) values between ~72.3 to 0.23 keV/μm. The presence of cystamine in irradiated Fricke solutions prevents the oxidation of FeThe accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author