High folic acid consumed during pregnancy promotes characteristics of metabolic syndrome in rat offspring. We hypothesized that folic acid alters the development of hypothalamic food intake pathways in utero, contributing to the metabolic phenotype of the offspring in later life. Pregnant Wistar dams were fed modified AIN-93G diets containing folic acid at: 0, 1.0 (control), 2.5, 5.0, or 10.0-fold of the recommended level. The folic acid content in the gestational diet was reflected in the expression of neuropeptide Y (NPY) neurons and body weight of the male offspring at birth. Low and high gestational folic acid led to higher food intake and weight gain in the offspring to 9 weeks post-weaning, consistent with decreased activity of pro-o...
[6S]-5-methyltetrahydrofolic acid (MTHF) is a proposed replacement for folic acid (FA) in diets and ...
The hypothesis that high multivitamin gestational (HV) diets affect the development of central serot...
The formation of the central nervous system occurs at an early stage of gestation and is followed by...
High folic acid consumed during pregnancy promotes characteristics of metabolic syndrome in rat offs...
High gestational folic acid (FA, synthetic folate) programs long-term metabolic consequences in the ...
The aim of this study was to understand whether high folic acid (HFA) exposure during the perigestat...
High (5-fold) folic acid (FA) diets during pregnancy result in obesity in rat offspring, associated ...
Prenatal nutritional constraint is associated with increased risk of metabolic dysregulation in adul...
Supplementation with [6S]-5-methyltetrahydrofolic acid (MTHF) is recommended as an alternative to fo...
Maternal intake of multivitamins or folic acid above the basal dietary requirements alters the growt...
The nutritional cues which induce different phenotypes from a single genotype in developing offsprin...
Pregnancy diet can impact offspring’s neurodevelopment, metabolism, redox homeostasis, and inflammat...
Copyright © 2013 Pedro S. P. Huot et al.This is an open access article distributed under theCreative...
Rats fed gestational diets high in multivitamin or folate produce offspring of altered phenotypes. W...
High vitamin (HV), AIN-93G diet with ten-fold the regular amount of vitamins (RV), consumed by pregn...
[6S]-5-methyltetrahydrofolic acid (MTHF) is a proposed replacement for folic acid (FA) in diets and ...
The hypothesis that high multivitamin gestational (HV) diets affect the development of central serot...
The formation of the central nervous system occurs at an early stage of gestation and is followed by...
High folic acid consumed during pregnancy promotes characteristics of metabolic syndrome in rat offs...
High gestational folic acid (FA, synthetic folate) programs long-term metabolic consequences in the ...
The aim of this study was to understand whether high folic acid (HFA) exposure during the perigestat...
High (5-fold) folic acid (FA) diets during pregnancy result in obesity in rat offspring, associated ...
Prenatal nutritional constraint is associated with increased risk of metabolic dysregulation in adul...
Supplementation with [6S]-5-methyltetrahydrofolic acid (MTHF) is recommended as an alternative to fo...
Maternal intake of multivitamins or folic acid above the basal dietary requirements alters the growt...
The nutritional cues which induce different phenotypes from a single genotype in developing offsprin...
Pregnancy diet can impact offspring’s neurodevelopment, metabolism, redox homeostasis, and inflammat...
Copyright © 2013 Pedro S. P. Huot et al.This is an open access article distributed under theCreative...
Rats fed gestational diets high in multivitamin or folate produce offspring of altered phenotypes. W...
High vitamin (HV), AIN-93G diet with ten-fold the regular amount of vitamins (RV), consumed by pregn...
[6S]-5-methyltetrahydrofolic acid (MTHF) is a proposed replacement for folic acid (FA) in diets and ...
The hypothesis that high multivitamin gestational (HV) diets affect the development of central serot...
The formation of the central nervous system occurs at an early stage of gestation and is followed by...