Synthesis and fluorescence spectral studies of novel quinolylbenzothiazole-based sensors for selective detection of Fe3+ ion

Four novel fluorescence sensors bearing quinolylbenzothiazole platform were synthesized and characterized. The sensors displayed excellent selectivity, high sensitive fluorescence response to Fe3+ ion in H2O/DMSO buffer solution (1:4, volume ratio, Tris-HCl 0.01 M, pH = 7.40) at 500 nm originating from quinolylbenzothiazole fluorophore group. Other cations viz. Li+, Na+, K+, Mg2+, Ca2+, Co2+, Ni2+, Cd2+, Cu2+, Zn2+, Mn2+, Ba2+, Pb2+, Hg2+, Al3+, Eu3+ ions showed no appreciable change in fluorescence spectrum. The binding stoichiometry between sensors L1, L2, L3 or L4 and Fe3+ were observed to be 1:1 based on fluorescence titration and Jobâ s plot analysis. The detection limits of L1, L2, L3 or L4 for Fe3+ were found to be 0.155, 0.362, 0.249, 0.517 ÎźM, respectively. Further, possible utilization of sensors as bio-imaging fluorescence to detect Fe3+ in living HeLa cells were also investigated by confocal fluorescence microscopy.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author