The impact of an acute oral phosphate load on endothelium dependent and independent brachial artery vasodilation in healthy males

Serum phosphate levels are associated with cardiovascular morbidity and mortality in the general population and endothelial dysfunction may be mechanistically involved. The purpose of this study was to investigate the effects of acute phosphate supplementation on endothelial-dependent (Flow mediated dilation (FMD)) and -independent (Glyceryl trinitrate (GTN)) vasodilation in young, healthy males. 17 healthy male participants (23Âą3 years old) were exposed to an oral load of phosphate (PHOS; (liquid supplement containing 1200 mg of phosphorous) and placebo (PLAC) over two experimental days. A brachial artery FMD test was performed pre- and 20 min, 60 min and 120 min following the ingestion of the phosphate load or the placebo. GTN tests were performed pre and 140 min post-ingestion. Serum phosphate was not impacted differently by phosphate vs. placebo ingestion (p=0.780). In contrast, urinary phosphate excretion was markedly increased in the PHOS (pThe accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author