A new concept based on the Picosecond Infrared Laser (PIRL) has been introduced to selectively excite water to directly drive ablation of biological tissue faster than any competing energy dissipation process that could damage surrounding tissue. This thesis work showed that this mechanism can be exploited for a new form of spatially resolved mass spectrometry with the prospect of near instant biodiagnostics with mass spectroscopic sensitivity. The ion source for imaging mass spectrometer was based on PIRL ablation with an electrospray pick up source to entrain the ablated species. This hybrid Picosecond Infrared Laser Assisted Electrospray Ionization (PIR-LAESI) showed a limit of detection of 100 nM and a spatial resolution of ~ 100 Îźm, l...
Laser ablation ESI (LAESI) is a recent development in MS imaging. It has been shown that lipids and ...
We report the soft laser extraction and production of highly charged peptide and protein ions for ma...
It was recently shown that sampling of tissues with a picosecond infrared laser (PIRL) for analysis ...
A new concept based on the Picosecond Infrared Laser (PIRL) has been introduced to selectively excit...
A picosecond infrared laser (PIRL) is capable of cutting through biological tissues in the absence o...
A picosecond infrared laser (PIRL) is capable of cutting through biological tissues in the absence o...
The prospects for minimally invasive surgery, spatial imaging with mass spectrometry and rapid high ...
The prospect for spatial imaging with mass spectroscopy at the level of the cell requires new means ...
A new mechanism has been discovered that completely arrests nucleation growth and eliminates associa...
The fundamental understanding of biochemical processes functioning in living organisms relies on the...
Background and Objectives A picosecond infrared laser (PIRL) has recently been demonstrated to cut b...
The analysis of proteomes directly from tissues requires the proteins to be released from the cells ...
Introduction: A novel method for ultrafast and soft cold vaporization of tissue via desorption by im...
Molecular dynamics simulations were performed to characterize the ablation process induced by a pico...
Laser ablation ESI (LAESI) is a recent development in MS imaging. It has been shown that lipids and ...
We report the soft laser extraction and production of highly charged peptide and protein ions for ma...
It was recently shown that sampling of tissues with a picosecond infrared laser (PIRL) for analysis ...
A new concept based on the Picosecond Infrared Laser (PIRL) has been introduced to selectively excit...
A picosecond infrared laser (PIRL) is capable of cutting through biological tissues in the absence o...
A picosecond infrared laser (PIRL) is capable of cutting through biological tissues in the absence o...
The prospects for minimally invasive surgery, spatial imaging with mass spectrometry and rapid high ...
The prospect for spatial imaging with mass spectroscopy at the level of the cell requires new means ...
A new mechanism has been discovered that completely arrests nucleation growth and eliminates associa...
The fundamental understanding of biochemical processes functioning in living organisms relies on the...
Background and Objectives A picosecond infrared laser (PIRL) has recently been demonstrated to cut b...
The analysis of proteomes directly from tissues requires the proteins to be released from the cells ...
Introduction: A novel method for ultrafast and soft cold vaporization of tissue via desorption by im...
Molecular dynamics simulations were performed to characterize the ablation process induced by a pico...
Laser ablation ESI (LAESI) is a recent development in MS imaging. It has been shown that lipids and ...
We report the soft laser extraction and production of highly charged peptide and protein ions for ma...
It was recently shown that sampling of tissues with a picosecond infrared laser (PIRL) for analysis ...