Effects of Telmisartan and Pioglitazone on High Fructose Induced Metabolic Syndrome in Rats

Metabolic syndrome (MS) is a cluster of hypertension, insulin resistance, dyslipidaemia and hyperuricemia. This study was designed to assess the effect of telmisartan and pioglitazone on high fructose induced metabolic syndrome.35 Male albino rats were classified into 5 groups: A: Normal diet-fed; B: High Fructose-fed (HFD) subdivided into B1 (HFD only), B2 (telmisartan 5mg/kg), B3 (pioglitazone10mg/kg) and B4 (telmisartan + pioglitazone). Drugs started 4 weeks after staring HFD lasts for 4 weeks. Body weight (BW), blood pressure (BP) measurement, estimation of the level of fasting glucose, fasting insulin, uric acid (UA), total cholesterol, triglycerides (TG), high density lipoprotein (HDL-c), low density lipoprotein (LDL-c), blood urea nitrogen (BUN), creatinine and (nitric oxide) NO were done. Compared to group-B1:Telmisartan sig decrease BP, BW, serum glucose, insulin, UA, urea, cholesterol, TGA, LDL and sig increase HDL; pioglitazone sig decrease BP, serum glucose, insulin, UA, urea, creat., cholesterol, TGA, LDL and sig increase HDL. Co-administration of Pioglitazone + telmisartan sig decrease insulin, urea and creat compared to telmisartan alone. Combined telmisartan plus pioglitazone allow better control of BP, hyperglycaemia, insulin resistance and the amelioration of BW increase that may be associated with pioglitazone treatment.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author